Learn how to properly carry out preventive measures using Rimantadine at a time when the risk of getting sick with ARVI and influenza arises.

With the onset of rainy autumn weather, the risk of various viral respiratory epidemics increases. To prevent them or lower the threshold of morbidity, people begin to take various preventive measures and take medications. From the TV screens you can see many suggestions on how to successfully prevent the development of such diseases with the help of various drugs. One of the known remedies for viral infections is Rimantadine. Let's find out how these pills work.

Rimantadine in tablets: what helps and what is its composition, active ingredient?

Colds can be called differently, but the root cause of their occurrence is the defeat of infections of various organs, in particular: the upper respiratory tract by harmful microorganisms. They are divided into two groups: bacteria, viruses.

Rimantadin according to the pharmacological group, it is an antiviral agent. Especially its effect is actively manifested at the initial stage of infection of the patient. The drug is available in the form of tablets in a regular carton box.

The active ingredient is rimantadine hydrochloride. One tablet contains fifty milligrams of active ingredient. There are also auxiliary elements: starch, lactose, calcium stearate, talc.

What diseases is the drug used for?

Rimantadine is used for the treatment, prevention of influenza infections, encephalitis. It is effective for colds, acute respiratory infections, tonsillitis, rotavirus and herpesvirus infections. This remedy has the ability to lower the temperature and relieve the symptoms of diseases at the first stage of the manifestation of the disease.

Rimantadin Avexima, Darnitsa, STI: release form, indications for use

Rimantadine is available in the form of flat-cylindrical tablets. Their color is white. Packed, as a rule, in a cardboard box of 20 pieces. One such tablet contains 50 mg of active ingredient.

This drug is especially active in the fight against influenza A viruses. It is a weak base and has a direct effect on the virus envelope. Rimantadine interferes with the transmission of the virus into the cytoplasm of a healthy cell. The dosage form helps to suppress the release of viruses from the envelope tissue.

The principle of the drug:

After the tablet is swallowed, absorption is slow. Almost all of the active ingredient is absorbed by the intestines. Metabolization occurs in the liver, and rimantadine is excreted through the kidneys.

Indications:

The remedy is indicated for the treatment of influenza infections of the A strain in adults, children from the age of seven.

Rimantadin: abstract, instructions for use and dosage for children with colds, SARS and for the prevention of influenza

The instructions describe in detail how to drink the drug for children, but the doctor can individually adjust the dose of rimantadine, depending on the characteristics of the body and the course of the disease.

• For children up to the age of seven it is not recommended to drink the medicine.
• And starting from seven to ten years old children are supposed to use 50 milligrams (1 tablet) - twice a day.
• FROM eleven to fourteen you should drink 1 tablet - three times a day.
• FROM 14 years old the drug is used according to the scheme for adults.

IMPORTANT: This remedy should be drunk only after meals, be sure to wash it down with water. The disease should be treated no later than a day or two after the first symptoms of its manifestation. For preventive measures, it is enough for children to drink just one tablet a day.

Rimantadin: abstract, instructions for use and dosage for adults for colds, SARS and for the prevention of influenza

At the first signs of the disease, adults should drink 300 mg at once once so that the virus does not spread further. Alternatively, this dose can be divided into three doses. Drink the drug with plenty of water and use only after eating.

On the second or third day of the course of the disease, it is enough to drink one hundred milligrams of the drug twice a day.

And on the fourth or fifth day - 100 milligrams once a day.

To do not get sick with influenza A, adults should within a month (ahead of time before the onset of the epidemic) rimantadine, one tablet per day.

What is the correct name for an antiviral drug: Remantadine or Rimantadine?
Rimantadine or Remantadine: what is the difference, the difference, which is better?

The correct name is both. There are two drugs that contain the same active ingredient... These tablets identical impact on the body and, practically, the same contraindications.

They have a slightly different price. Remantadine is worth a little more expensive rimantadine. Also, the first drug is produced in various dosages. Rimantadin it has a dosage only - fifty milligrams.

Rimantadine tablets: contraindications, side effects

As with other drugs, rimantadine there are a number contraindicationsby application.

1. Exacerbation of pathologies of the liver, gallbladder.
2. Do not use an antiviral agent if the patient has kidney disease.
3. In case of allergic reactions to any components of the dosage form, its intake is prohibited.
4. It is better for babies under the age of seven to take other drugs - this medicine is contraindicated for them.
5. Do not drink rimantadine for pregnant, lactating, thyrotoxicosis patients.
6. Patients who are lactose intolerant will also not be able to take the drug.

Among other things, use rimantadine with extreme caution if you have: hypertension, atherosclerosis, diseases nervous system (epilepsy), liver failure, gastrointestinal tract pathologies.

The dosage form must be canceled if the following symptoms occur:

• Rash on the skin, itching
• CNS disorders are manifested: insomnia, headaches, drowsiness, anxiety, fatigue, dizziness.
• In case of malfunctions of the digestive system: vomiting, loss of appetite, dry mouth, pain in the abdominal part of the body, etc.

Rimantadine tablets: alcohol compatibility

There is no information in the instructions on the interaction of these tablets with strong drinks. And yet, despite this, the patient will not hurt to give up alcohol while taking the drug. Because, like alcohol and without anything else, it weakens the immune system of the human body. therefore the beneficial effect of the pills will come to naught... All infection control efforts will be futile.

If, in addition to rimantadine, you also drink alcohol, then effects on the liver will be aggravated... Pills, albeit a little, but disrupt the normal functioning of the liver, and even more alcohol. This double exposure can be a big problem for the patient.

And if you have already taken a certain dose of alcohol, then it is better not to drink the drug. The minimum gap between the hot drink and the tablets should be - six hour break.

Moreover, if you use these incompatible components, then a person may have central nervous system disorders: loss of orientation, nervousness, other disorders - up to severe depression.

Therefore, you should not experiment with your body. Do not drink alcohol during treatment with rimantadine.

Rimantadine tablets: analogues

This drug has several analogues. These include:

• remavir, remantadine
• orvirem, polirem
• rimantadine-aktitab, rimantadine-STI
• rimantadine hydrochloride

Rimantadine tablets: reviews

According to the reviews of patients who used the drug, it can be concluded that the drug really has a beneficial effect in type A influenza diseases. Many more emphasize that the drug has more low pricethan the same dosage forms with similar effects.

Antiviral Rimantadine - prevents the whole family from getting sick

Sofia, 36 years old:

It has an effect on the primary signs of the onset of the disease. It took five days to completely get rid of a cold. Moreover, I drank the tablets not according to the regime, but whenever possible.

Nikolay, 39 years old:

When my child reports that there are already many sick in the classroom, I give him rimantadine, one tablet a day. Therefore, the son does not miss classes. It is better to prevent the disease in advance than to treat it later.

Video: Rimantadin - application, analogues

Kagocel is a representative of the group of systemic antiviral drugs, which has a pronounced immunostimulating effect. As a result of its intake, the pathogenic microflora dies, due to which the development of the disease is suspended.

However, due to the rather high cost, or intolerance of the active substance, the patient has to choose an analogue of Kagocel, only cheaper. How the drugs differ and which one will be more effective, read below.

The mechanism of action of Kagocel is based on stimulating the production of interferon. In this case, mainly "late" interferons are produced, which are a mixture of - and - fractions.

Endogenous interferon promotes the formation of an immune response. Unlike exogenous, which is administered in the form of finished medicines, endogenous interferon has practically no side effects.

Kagocel exhibits high antiviral activity. The active ingredient of the drug - Kagocel 12 mg prevents the penetration of viral agents into the cells of the body, thereby blocking the further development of the infection.

After taking a pill with a dose of 12 mg, the concentration of interferons reaches a maximum after 48 hours. Due to their prolonged action, interferons circulate in the blood for 5 days. Only 20% of a single dose of Kagocel enters the general bloodstream. It is excreted mainly in the feces and only about 10% in the urine. The maximum therapeutic effect from taking the drug is observed only on the 3rd day after the start of therapy.

When the drug is taken in doses not exceeding therapeutic doses, it does not accumulate in the body. Kagocel does not exhibit mutagenic, teratogenic, embiotoxic properties.
It is most advisable to start taking the drug no later than on the 4th day of the onset of ARVI symptoms. The drug is used in the therapy of adults and children over 3 years old.

According to the instructions for use, Kagocel is effective:

• in the treatment of viral infections and as part of prophylaxis after contact with a sick person, during a seasonal epidemic;
• for the treatment of herpes infection in adults in active phase, which is confirmed by the results of laboratory tests;
• in complex.

Admission rules and dosages

You can take the drug regardless of food intake, since there are no other instructions in the instructions. The tablet should not be chewed, it should be washed down with a sufficient amount of water. However, it should be borne in mind that the joint administration of Kagocel with other antiviral, antibacterial, immunostimulating agents enhances the pharmacological effect of each of them.

There are several schemes for taking Kagocel, indicating the dose and duration of treatment, depending on the patient's age.

Adult patients, adolescents from 12 years old:

• therapy of influenza types A and B, other viral infections: three times a day for 2 days, 24 mg (2 tab), preferably at the same time, another 2 days - 12 mg (1 tab). The course of admission is 4 days.
• In order to prevent ARVI during a seasonal epidemic: once a day, 24 mg for 2 days, next take in 5 days. A prophylactic course can last up to 3-4 months.
• After contact with a sick person 24 mg per day, this dose must be repeated 2 days in a row.
• For the treatment of herpes infection, a single dose is 24 mg, which corresponds to 2 tab. It should be taken three times a day, the course of administration is 5 days.
• For children over 3 years of age, the recommended single dose is 12 mg, or 1 tablet:
  therapy of viral diseases in children 3-6 years old: a single dose twice a day for 2 days, the next 2 days - a single dose a day. The course of treatment is 4 days. Children 6-12 years old are recommended to take 12 mg three times a day for 2 days, then another 2 days 12 mg twice a day.
• For prophylaxis during a seasonal epidemic, the regimen is the same as for adult patients. A single dose is 12 mg. The prophylactic reception can be repeated for several months.

Contraindications

Kagocel should not be taken with increased susceptibility to the main and auxiliary components of the drug, deficiency of the lactase enzyme, lactose deficiency (lactose is an auxiliary substance), disorders of the digestive tract, taking into account glucose-galactose malabsorption.

Since special clinical studies have not been conducted, the drug is contraindicated in pregnant women and women during lactation, children under 3 years of age.

Side effects and overdose

Kagocel is one of the few drugs with a minimal set of possible side effects. When taken, hypersensitivity reactions sometimes appear in the form of drug urticaria, exacerbation of atypical dermatitis.

Cases of drug overdose are extremely rare. This condition is characterized by the appearance of nausea, vomiting, dizziness, stomach pain, diarrhea. To eliminate these symptoms, it is recommended to drink abundant drink, enriched with electrolytes, vomiting should also be provoked, after which sorbents and other detoxifying agents are shown. There is no specific antidote.

List of cheaper analogues

Kagocel is an antiviral drug in the middle price category. The cost of package No. 10 ranges from 195 to 260 rubles. However, many are trying to find analogues of kagocel, the cost of which will be lower.

It should be borne in mind that there are no drugs absolutely identical (structural substitutes) to it.

Below is a list of drugs similar to Kagocel in terms of therapeutic action:

• Acyclovir 200 mg No. 20 - 40 rubles;
• Remantadine tab. No. 20 of a domestic manufacturer - 75 rubles, an import one - 180;
• Antigrippin homeopathic children's granules 10 g No. 2 - 95 rubles, tab. No. 40 - 100 rubles;
• Anaferon No. 20 - 180 rubles;
• Cycloferon tab. 150 mg No. 20 - 180 rubles;
• Amizon 250mg No. 10 - 200 rubles.
• Citovir-3 in the form of syrup - 385 rubles, caps. No. 12 - 335 rubles;
• Arbidol: capsules of 100 mg No. 10 - 245 rubles, No. 20 - 480 rubles, 200 mg No. 10 - 465 rubles;
• Ingavirin caps. 60 mg No. 7 - 425 rubles, 90 mg No. 7 - 505 rubles.

The list of the most budgetary substitutes includes:

• Acyclovir;
• Remantadine;
• Antigrippin;
• Anaferon;
• Cycloferon;
• Amizon.

It should be borne in mind that cheaper drugs can be more expensive, due to the peculiarities of the reception and the different duration of treatment courses. For the same reason, more expensive drugs can be cheaper for the patient.

Some of the drugs exhibit more pronounced antiviral activity, and some are more convenient to take. Below we compare Kagocel with its analogues and highlight the advantages and disadvantages of both drugs.

Antigrippin or Kagocel

Antigrippin is homeopathic remedy, which contains plant and mineral ingredients. It exhibits antipyretic, adaptogenic, immunomodulatory, anti-inflammatory effects. In addition, the indisputable advantages of the analog are:

• lack of side effects;
• approved for use in children over a year old;
• contraindicated only in case of intolerance to the components of the drug;
• has a mild action.

However, antigrippin should be taken as soon as possible after the onset of malaise and the first signs of SARS in a child, only in this case it will be effective. With a complicated course of viral lesions, it is a component of complex treatment. In addition, the course of treatment is about 10 days, which is not suitable for all patients.

Arbidol or Kagocel

The Russian analogue of Kagocel - has a double action and is more expensive analog... The drug has a powerful immunomodulatory and antiviral effect. In addition, its cost is much lower than that of Kagocel.

In the treatment of influenza and other infections provoked by viral agents, Arbidol will be more effective than Kagocel.

In addition, it is used in complex treatment rotavirus infection, secondary immunodeficiency states, diseases of the lower respiratory tract, including pneumonia and bronchitis.

When taken as a prophylactic agent, the likelihood of infection is significantly reduced, and if a person is still sick, the symptoms of ARVI are mild.

However, since Arbidol has a wider spectrum of action, there are also more contraindications, which should be taken into account when taking the drug. Therefore, it is Kagocel that is considered safer and more effective.

Kagocel or Cycloferon

Cycloferon is the closest substitute for Kagocel in terms of therapeutic effect. This drug also stimulates the induction of interferon and exhibits an indirect antiviral effect, restoring humoral and cellular immunity.

It is prescribed in the complex treatment of neuroinfections, chlamydial and cytomegalovirus infections, arthritis, hepatitis of viral etiology, HIV, systemic lupus erythematosus.

Cycloferon is produced in several dosage forms, approved for use in children. However, the drug is contraindicated in gastric ulcer, acute current gastritis, liver diseases, increased tendency to develop allergies, children under 4 years of age (Kagocel is allowed from 3).

In the course of laboratory studies, the ability of acridineacetic acid to penetrate into breast milk and through the hematoplacental barrier has been proven, therefore cycloferon is contraindicated in pregnant women, during breastfeeding. In this case, Kagocel is a more versatile drug that is suitable for the treatment of adults and children.

Remantadine or Kagocel

The cheapest analogue of Kagocel is Russian remantadine. This drug exhibits antiviral activity against influenza A and B viruses, tick-borne encephalitis, in addition, it has an immunomodulatory and antitoxic effect.

However, it is not compatible with medicines containing acetylsalicylic acid and paracetamol.

Remantadine is contraindicated in children under 7 years of age, with kidney pathologies, epilepsy, thyrotoxicosis, pregnant women, and during lactation can only be used with caution.

When taking remantadine, side effects often develop in the form of vomiting, nausea, diarrhea, sleep disturbances, headaches, and overexcitation.

The drug can be taken for prophylaxis for a long time. In this case, the likelihood of contracting viral infections is reduced.

Kagocel or Ingivirin - which is better

Ingavirin is similar to Kagocel in its mechanism of action. The main component of the drug is vitaglutam.

The cost of the analogue is slightly higher than Kagocel. However, it should be borne in mind that according to the instructions, Ingavirin should be taken in 1 caps. once a day for 7 days. That is, one package is enough for the course.

Treatment should be started no more than 2 days after the onset of symptoms. While Kagocel is effective when starting therapy on the 4th day of infection. However, one package will not be enough for a course of treatment for an adult.

Ingavirin is characterized by a triple action, although it does not have a direct effect on viral agents:

• stimulates an increase in receptors on the surface of an infected cell, which are characterized by increased susceptibility to interferon;
• activates the production of its own interferon;
• inhibits the production of biologically active substances, in particular COX, which provoke the development of inflammation.

Ingavirin, unlike Kagocel, cannot be taken for a long time as a prophylactic agent.

Kagocel or Tsitovir-3

Tsitovir-3 is a relatively inexpensive analogue of Kagocel. It is a bendazole-based immunomodulator, which is enhanced by sodium thymogen (stimulates T-cell immunity) and ascorbic acid (activates humoral immunity, normalizes vascular permeability, reduces the intensity of inflammation).

When the drug is taken, the synthesis of interferon is stimulated, enzymes are activated that prevent the replication of viruses.

Let's summarize

Kagocel has no absolute analogues, so the doctor can choose a drug similar in its mechanism of action. However, it is undesirable to replace the drug on your own. After all, the selection of any medicine, including antiviral and immunomodulatory drugs, is based on the severity of the disease, the main clinical manifestations and complaints of the patient, the presence of chronic diseases in the anamnesis.

It must be remembered that the wrong drug will do more harm than good.

In contact with

Rimantadine is an inexpensive antiviral agent. It is effective on early stages infection, in the later stages does not bring tangible results. See the photo below.
Dosage form - tablets, capsules, syrup (for children).

Composition

The drug is produced by various manufacturers in the form of capsules, tablets, syrups (for children).
Each tablet contains 50 mg of the active ingredient - rimantadine hydrochloride. Auxiliary chemical components - lactose monohydrate, potato starch, stearic acid, aerosil, microcrystalline cellulose.

Rimantadine tablets from what they are, indications for use

The active component of the drug is a derivative of adamantane, which has an antiviral effect. The therapeutic effect is achieved due to the ability of rimantadine to block the entry and reproduction of the virus in the viral cells of the body. Because of this, the maximum effect of the drug is achieved in the initial stages of penetration of the virus into the body, but is ineffective at the height of the disease.

The drug is used in the prevention and treatment of any type of influenza type A virus (including swine flu), herpes, and has an anti-toxic effect in cases of influenza B. For colds, it is ineffective.

It is prescribed as a prophylactic agent for tick-borne encephalitis (for example, after a tick bite).

Cheap analogues

Rimantadine is relatively inexpensive (compared to others), but it also has cheaper analogues.

Among these are:

• 1 "Rimantadit Aktitab"
• 2 "Rimantadin-Darnitsa", Kiev, Ukraine
• 3 "Remantadin"
• 4 "Rimantadin-sti"
• 5 "Remavir"
• 6 "Remantadin Avexima"
• 7 "Amantadine"
• 8 Tamiflu (Oseltamivir)
• 9 "Zanamivir"
• 10 Orvirem (syrup for children).

All these analogs are similar in pharmacological action, only the active ingredient, method of administration, cost differ (although prices in Moscow, Odessa and Yekaterinburg for the same drug may also differ significantly).

Rimantadin and Remantadin what is the difference?

Both rimantadine and rimantadine are antiviral drugs used for influenza and SARS. The difference is that RIMANTADIN is the active ingredient and the more common name of the drug, and REMANTADIN is the commercial name of the drug from one of the manufacturers. This is their main difference. That is, it is one and the same drug, differently named by its manufacturers, but identical in chemical composition.

Rimantadine tablets instructions for use for children

Before taking the drug, you should definitely consult with your doctor.

• 1 - 3 years - on the first day 30 ml, on the second and third - 20 ml, on the fourth and fifth - 10 ml;
• 3 - 7 years - the first day - 45 ml, the second and third days - 30 ml, the next two days - 15 ml;
• 7 - 14 years old - on the first day of admission - 60 ml, then two days for 40 ml, the next two days for 20 ml.
• up to a year - it is forbidden to take.

Attention!

The dosage is calculated on the basis of 1 teaspoon - 5 milliliters.

How to take rimantadine actitab tablets?

Admission in the form of capsules and tablets is allowed for adults and children over 7 years of age according to the following regimen:

• children aged 7 - 10 years - 100 milligrams daily for no more than 5 days;
• children aged 11-14 years - 150 mg daily for five days;
• all over 14 years old - on the first day of admission - 300 mg, the second and third - 200 mg, in the next two days of admission - 100 mg each.

It should be taken before meals, three times a day, dividing the dose for several times.

For adults with colds

With ARVI, taking remantadine is inappropriate, because it is not a broad-spectrum antibiotic. For colds, amoxicillin and its derivatives will be more effective.

For prophylaxis dosage

For preventive purposes, you can take one tablet for adults no longer than 30 days, and for children, the most acceptable syrup with rimantadine will be 2 (up to three years) or 3 (up to 7 years) teaspoons per day for 10-15 days, - in order to prevent tick-borne encephalitis - only as prescribed by specialists, 2 tab. three days.

How much is prescribed during pregnancy?

During pregnancy, therapy with rimantadine is prohibited. During lactation, the drug is mixed in case of termination of breastfeeding of the child.

Remantadine reviews for children

As to whether it is possible to give the child at the initial stage of these drugs, there is an ambiguous opinion. If something is written in a Wikipedia article, then it is automatically considered correct, even if the creator of the article is not aware of the topic. Many people trust opinions on forums, medical sites.

Nikolay: “Now there is such a huge amount of advertising for expensive drugs, but nothing has been heard about Remantadin for a long time. Although in my family he is always in the first-aid kit in case of flu. "

Victoria: “I have two children, at the onset of the disease I save them with rimantadine (although Komarovsky also says that it is better to temper, play sports, than feed with medicine). I give the little one a syrup, but the elder Dima is already taking pills, though he complains that they are bitter. "

Snezhana: “In the current conditions of economy, Rimantadin is the very thing. I always use it at the first symptoms of the flu, and I give it to my husband and children. It always helps, and no one has any side effects, not even once. "

Tamara: “I heard that girls drink rimantadine for weight loss. Quite silly, because it's antiviral. If you drink more than the daily dose, then there is a risk of unwanted effects, and even poisoning. "

Contraindications

The drug should not be taken by such groups of people:

• in the presence of sensitivity to rimantadine hydrochloride;
• with diseases of the liver and kidneys;
• with thyrotoxicosis;
• arterial hypertension;
• pregnant and lactating.

You should also exclude the simultaneous use of this medication with alcohol,

Side effects

In general, side effects are rare. Possible reactions of the digestive system: flatulence, nausea, vomiting, dry mouth, pain, anorexia.

Also, there may be reactions of the central nervous system to taking the drug: anxiety, headache, insomnia, irritability, drowsiness, fatigue, dizziness.
Also, in some cases, allergic reactions occur.

Influenza A is the predominant type of virus, accounting for 99% of cases per year. Despite the widespread spread of influenza and the huge amount of funds that are spent in different countries There are not so many drugs with direct antiviral activity to combat it.

In fact, there are only two classes of such substances: neuraminidase inhibitors (Tamiflu, Relenza) and adamantane derivatives. The latter include rimantadine, which is part of many anti-influenza drugs, for example, AnGriCaps,

A natural question may arise: what is the difference between "rimantadine" and "rimantadine"? It's simple: the one that through the "and" is the name of the substance of which the drug is composed, and through the "e" it is one of the many trade names (brands) under which this substance is sold. For example, drugs called Rimantadin-Sti, Rimantadin-Aktitab. Thus, the practical difference here can only be in the price, form of release or dosage, but not in the active substance itself.

20 tab.

Another group of antiviral drugs based on immunotropic action is also popular in the fight against influenza. Its representative is Kagocel.

What is the difference?

There are contraindications, use in consultation with your doctor

Both drugs belong to the pharmacological group of antiviral drugs. The chemical name of the active ingredient of Remantadine is 1- (1-adamantyl) ethylamine hydrochloride. Other names are the aforementioned rimantadine or meradan. The drug is produced by the Latvian company Olainfarm in two forms: capsules with powder (100 mg each) and tablets (50 mg each). Remantadin tablets in the same dosage can also be found from domestic manufacturers (Biochemist Saransk, Rozpharm LLC).

The difference between Kagocel is that this drug has been developed, synthesized and put into production in Russia. It is produced by NEARMEDIC PLUS in the form of tablets with an active ingredient concentration of 12 mg. According to the manufacturer, it is effective at a later start of treatment.

Naturally, both preparations contain excipients that provide the necessary technological properties to the tablet forms.

The difference in the mechanism of action

Rimantadin was discovered long ago, back in 1963. It was found that it acts on the replication system of the virus, preventing it from multiplying in cells. However, it is only active against influenza type A.

If the action of Rem-n can be compared with a direct shot at a target-virus, then the Kag-la effect develops according to the "domino principle", when the first falling knuckle leads to a whole chain of events. This is how it initiates the production of interferons in cells, which trigger a sequence of immune responses leading to the destruction of the virus, thus the mechanisms of their action are completely different.

Advantages and disadvantages

There are some peculiarities that you need to be aware of when choosing one of the drugs. Since rimantadine has been used in the practice of treating influenza infection for more than forty years, according to some data, resistance has developed to it. For example, the 2011 Recommendations of the Advisory Committee on Immunization Practices (ACIP, USA) contain a warning against its use. They report the results of studies from 2005-2006, which showed that 92% of influenza A cases were resistant to adamantanes.

The advantages of Kagocel can be written down that viruses cannot develop resistance to it, since the principle of action is different. Interferon molecules do not care how the virus changes; all the same, the "enemy" will be detected and neutralized. But he also has his own weak spots... This substance was synthesized in Russia not so long ago, so it cannot be said that the clinical experience and geography of its use are extensive.

The main chemical compound Kag-la is synthesized on the basis of a substance gossypol, which, in addition to excellent virucidal and bactericidal properties, can inhibit spermatogenesis and cause infertility. In the preparation, gossypol is in a bound state. It is believed that Kagocel does not break down in the body to gossypol, but direct evidence has not yet been obtained. Therefore, there is a possibility (albeit minimal!) Of accumulation of gossypol to toxic concentrations with frequent use of the drug. This is especially dangerous in childhood and adolescence, when the reproductive system is forming and maturing.

Application and contraindications

The main purpose of both drugs is anti-influenza therapy. Kag-l can also be used for other respiratory viruses and. The difference in the testimony of the opponents is insignificant. In addition to the treatment and prevention of influenza, Rem-n is prescribed for the prevention of tick-borne viral encephalitis.

The table shows that Remn has more contraindications, which is due to the peculiarity of the biological action and excretion of adamantanes from the body.

About the cost of drugs

When comparing price characteristics, you can see a significant difference. If 10 Kag-la tablets cost from 220 to 234 rubles, then 20 Rem-na tablets cost from 54 to 170 rubles. For the course of influenza treatment, an adult will need 18 Kag-la tablets (2 packs), that is, about 450 rubles. It turns out that the course of treatment will cost them 3-8 times more than Remnom.

Rimantadine and Rimantadine belong to the class of antiviral drugs. They have been widely used in the treatment of acute diseases for over 50 years. Even now, when you go to the doctor with complaints about characteristic symptoms cold or flu, the patient will most likely be prescribed or. Such a sustainable application practice is due to the high pharmacological qualities of these drugs:

• security;
• high bioavailability;
• prolonged action;
• strengthening the body's immune response.

Key differences between rimantadine and rimantadine

Rimantadine is the official name for an antiviral chemical. The drug was patented back in 1965 - during this time, several dozen drugs of various effectiveness were released, based on rimantadine. Thus, rimantadine is pure chemical substance, and its analogues contain additional components.

The most popular analogue is rimantadine, which contains many auxiliary components. Some of them are ballast substances, others increase the pharmacological effectiveness of the drug. It is worth noting that rimantadine is much cheaper than remantadine: prices for the latter range from 100 to 300 rubles, while rimantadine will cost a maximum of 85 rubles per pack.

In addition to the price, both drugs differ from each other only in dosage: rimantadine is produced in tablet form with an active ingredient content of 50 mg. The amount of active ingredient in remantadine ranges from 50 to 100 mg.

It is important to bear in mind that purchasing and taking cheaper analogs of rimantadine on your own can slow down the healing process, and in some cases cause serious complications. Always follow your healthcare provider's recommendations and only take certified medicines.

Drug action: pharmacology and pharmacokinetics

Rimantadine, as well as all its analogues (including rimantadine), has good bioavailability. When taken orally, they are completely absorbed into the small intestine within the first hour. It binds to blood proteins for more than 24 hours, which explains the duration of its action. It is metabolized by liver enzymes, after which it is excreted by the kidneys, without causing any harm to the body.

Both drugs have an antiviral nature of action, suppressing most of the known strains. They also deactivate viruses that cause, and. Efficiency against viruses is due to the ability of rimantadine to prevent the penetration of viral particles into the cells of the human body. In addition, the drug stimulates the natural immune processes in the body, has a mild anti-toxic and anti-allergenic effect.

If we compare the effectiveness of rimantadine and rimantadine, then their indicators are almost identical. The only difference is the increased concentration of active ingredients in remantadine, which somewhat speeds up the healing process. On the other hand, a higher dosage increases the risk of side effects. When choosing a medicine, you must adhere to the prescriptions of the therapist.

Indications for use

Rimantadine is prescribed as the main drug for the treatment of colds and flu. In complex therapy with other drugs, it is used to treat more serious pathologies: encephalitis, herpes, hepatitis and neoplastic diseases. Unfortunately, at the moment rimantadine is no longer the most effective antiviral drug. Many viruses have developed resistance to its effects - for this reason, rimantadine is not able to cope with serious diseases on its own.

It should be noted that rimantadine is widely used as a prophylactic agent. It is prescribed for those at risk of influenza epidemics, as well as for those with reduced immune function. The drug helps to improve the body's immune response, stimulates the production of antibodies and specific cells. Remantadine, being an analogue of rimantadine, has similar indications given its increased dosage.

Despite the fact that rimantadine and rimantadine are almost identical in their effectiveness and composition, the instructions for their use have some discrepancies. They are associated both with a non-uniform dosage and with the presence of additional components in the composition of remantadine.

For prophylaxis, rimantadine is taken once or twice a day, the recommended dosage is 100 mg (two tablets). The dosage for children is calculated based on their body weight - no more than 5 mg per kilogram. Remantadine for the same purposes is prescribed in an amount of no more than 50 mg per day due to its higher activity.

Therapeutic dosages can be adjusted as directed by a physician, not exceeding 300 mg once. To reduce irritation, rimantadine is taken afterwards on a full stomach.

Side effects and contraindications

Rimantadine and rimantadine are strictly contraindicated. during pregnancy or breastfeeding, as well as infants (up to one year old). With extreme caution, they are prescribed for any pathologies of the kidneys or liver - in this case, the reception is carried out under the strict supervision of the attending physician. Other contraindications include allergic reactions, individual intolerance and epilepsy.

The risk of side effects and their nature is almost identical for the two drugs:

• dizziness;
• increased fatigue;
• dry mouth;

When treating with rimantadine, you should refrain from taking paracetamol and other NSAIDs, do not consume alcohol and excessively spicy or fatty foods.